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17-AAG

1 mg

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Cat No. 10-G06

Availability: In stock

Regular Price: $99.00

Special Price: $10.00

Bulk Quantities Available

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Description

17-AAG is a synthetic derivative of geldanamycin and acts as an anti-tumor agent. 17-AAG binds specifically to heat shock protein Hsp90. Hsp90 is a protein chaperone that binds to client proteins. Client proteins include important cancer– relevant targets such as mutated p53, Her2, Bcr-Abl, Raf-1, Akt and others. 17-AAG disrupts the Hsp-900 client protein complexes and leads to the degredation of the client proteins. 


 

17-AAG

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TECHNICAL INFORMATION

 Other Names: NSC 330507 , 17-(Allylamino)-17-demethoxygeldanamycin, 17-Demethoxy-17-(2-propenylamino)geldanamycin

Chemical Formula:  C31H43N3O8

CAS Number: 75747-14-7

Molecular Weight: 585.69

Purity:  >99%

Appearance: purple solid

Solubility: DMSO, ethanol

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 150mg/ml. Soluble in ethanol at 5mg/ml. Very poorly soluble in water.

 

References

 

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