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IWP-2

2 mg

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Cat No. 57-G89

Availability: In stock

$99.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

IWP-2 is an inhibitor of Wnt production and an inactivator of Porcn function.  The Wnt/b-catenin pathway maintains transcriptional programs that enable stem cells to remain multipotent and hyperactivation of this pathway leads to disease stage. IWP-2 inactivates Porcn function by either directly inhibiting the Porcn active site or by modulating the function of the Porcn regulator.


 

IWP-2

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TECHNICAL INFORMATION

 Other Names: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Chemical Formula: C22H18N4O2S3

CAS Number: 686770-61-6

Molecular Weight: 466.60

Purity:  >98%

Appearance: White Powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 5mM concentrated stock solution, reconstitute the compound by adding 858 µl of DMSO to the entire contents of the vial. For most cells, the maximum tolerance to DMSO is <0.5%. 

 

 

References

 

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