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PD173074

2 mg

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Cat No. 14-Z32

Availability: In stock

$79.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. It has been shown to arrest the G0/G1 phase of FGFR3– expressing cells.  PD173074 blocks the FGFR signaling pathway and leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 has been shown to dramatically decrease their differentiation potential and clonogenicity. 


PD173074

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TECHNICAL INFORMATION

 Other Names: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)urea

Chemical Formula: C₂₈H₄₁N₇O₃

CAS Number: 219580-11-7

Molecular Weight: 523.67

Purity:  >98%

Appearance: Crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 100 mM. For a 10mM concentrated stock solution, reconstitute the compound by adding 382µl of DMSO to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells the maximum tolerance to DMSO is <0.5%.   

 

 

References

 

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