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PS48

5 mg

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Cat No. 16-M34

Availability: In stock

$69.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1) that binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of the only allosteric compounds that targets a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlaps with the ATP binding site. PS48 has been shown to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).


PS48

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TECHNICAL INFORMATION

Other Names: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

Chemical Formula: C17H15ClO2

CAS Number: 1180678-32-7

Molecular Weight: 286.75

Purity: ≥98% by HPLC

Appearance: Off White Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO >20mg/ml. Note, for most cells, the maximum tolerance to DMSO is <0.5%.

 

References

 

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