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SB431542

5 mg

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Cat No. 21-A94

Availability: In stock

$84.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

SB431542 is a selective and potent inhibitor of TGFβ superfamily type I activin receptor-like kinase (ALK) receptor, specifically ALK4, ALK5 and ALK7. It does not affect BMP receptors ALK2, ALK3 or ALK6. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. When used in combination with MEK inhibitor PD0325901, SB431542 has been found to enhance reprogramming efficiency.

SB431542

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  • SB431542

Details

TECHNICAL INFORMATION

Other Names: 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide

Chemical Formula: C22H16N4O3

CAS Number: 301836-41-9

Molecular Weight: 384.39

Purity:  ≥98%

Appearance: A crystalline solid

Solubility: DMSO, Ethanol

Working Concentration: 2µM

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (20mg/ml). Soluble in ethanol (2mg/ml). Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

 

References

 

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