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Small Molecules

What's a Small Molecule?

A small molecule is a fast working compound that has an effect on protein function. Small molecules can function across a variety of cell types and species and show great potential for use in therapeutics. Small molecules are unique in that they can inhibit a specific function of a multifunctional protein. They can also disrupt protein-protein interactions. Small molecules are also useful in that they can often be reversed or turned off if needed.

One of the keys to the effectiveness of a small molecule is its purity. You can compare our small molecules to our competitors. The formula is the same. The structure is the same. The molecular weight is the same. Our purity is the same or better. Our molecules look the same, feel the same and work the same or better...all at a more attractive price. Order today at Reagents Direct and take the next step in your research. Order now and your order can be shipped out today!


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  1. 17-AAG
    17-AAG

    Regular Price: $99.00

    Special Price: $10.00

    17-AAG is a synthetic derivative of geldanamycin and acts as an anti-tumor agent. 17-AAG binds specifically to heat shock protein Hsp90. Hsp90 is a protein chaperone that binds to client proteins. Client proteins include important cancer– relevant targets such as mutated p53, Her2, Bcr-Abl, Raf-1, Akt and others. 17-AAG disrupts the Hsp-900 client protein complexes and leads to the degredation of the client proteins. 

     

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  2. A-922500
    A-922500
    $150.00

    A-922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor for both human and mouse. DGATs catalyze the final reaction step in the synthesis of triglyceride. Learn More
  3. A769662
    A769662
    $99.00

    A769662 is a potent and reversible small molecule that activates AMP-activated protein kinase (AMPK). The activation of AMPK inhibits mTOR (mammalian target of rapamycin) signaling, which is a positive effector of cell growth, proliferation and survival. A769662 has been shown to inhibit the Na⁺K⁺-ATPase at higher concentrations. It also inhibits the differentiation of adipocytes. Learn More
  4. A83-01
    A83-01
    $99.00

    A83-01 is a TGFβ kinase/activin receptor like kinase (ALK5) inhibitor. It blocks the phosphorylation of Smad2 and inhibits TGFβ-induced epithelial-to-mesenchymal transition. A83-01 is more potent than small molecule SB431542, and has been shown to inhibit differentiation of rat induced pluripotent stem cells (iPSCs) and increases clonal expansion efficiency. Small molecule A83-01 helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.

     

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  5. Abiraterone
    Abiraterone
    $109.00

    Abiraterone is a potent steroidal inhibitor of cytochrome P450 CYP17 with an IC50 at 4 nM. Abiraterone has been shown to selectively inhibit the target enzyme, resulting in inhibition of testosterone production in both the adrenals and the testes.

     

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  6. Anacardic Acid
    Anacardic Acid
    $89.00

    Anacardic acid is a histone acetyltransferase (HAT) inhibitor. It inhibits the HAT activity of the transcription co-activators p300 and p300/CREB-biding protein associated factor (pCAF) with IC50 values of 8.5 and 5 µM. It has been shown to display a variety of biological activities, including antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition. Anacardic acid has been shown to decrease expression of NF-κB regulated gene products including, invasion, inflammation, proliferation and cell survival. It has also been linked to be a potent activator of Aurora Kinase A (ARK-1) mediated phosphorylation of histone H3.

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  7. AT13387
    AT13387
    $280.00

    AT13387 is a synthetic, small-molecule inhibitor of heat shock protein 90 (Hsp90). It selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins. Learn More
  8. AT9283
    AT9283
    $100.00

    AT9283 is a multi-targeted kinase inhibitor of both Aurora kinases (A & B) as well as Janus kinase (Jak) 2. It also targets serine/threonine protein kinases associated with myeloid cell proliferation. AT9283 inhibited growth and survival of multiple solid tumor cell lines. Learn More
  9. AZD1480
    AZD1480
    $100.00

    AZD1480 is a potent JAK2 inhibitor that can suppress growth, survival, as well as FGFR3 and STAT3 signaling and downstream targets. AZD1480 is a potent, competitive small-molecule inhibitor of JAK1/2 kinase, and is capable of inhibiting STAT3 phosphorylation and tumor growth in a STAT3-dependent manner. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. Learn More
  10. Bafilomycin A1
    Bafilomycin A1
    $135.00

    Bafilomycin A1 is a macrolide antibiotic that selectively inhibits vacuolar-type (v-type) H+ ATPase. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, E. coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. It blocks pH regulation in brain cells. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Learn More
  11. BAY 11-7082
    BAY 11-7082
    $75.00

    Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation. The transcription factor NF-κB plays a key role in regulating over 150 target genes that include the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules.  Bay 11-7082 selective and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting IκB-α phosphorylation.  BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1.

     

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  12. BEZ235 (NPV-BEZ235)
    BEZ235 (NPV-BEZ235)
    $99.00

    NPV-BEZ235 is a dual inhibitor of phosphatidylinositol 3-kinase (P13K)and the downstream mammalian target of rapamycin (mTOR) by binding to the ATP-binding cleft of these enzymes. It specifically blocks the dysfunctional activation of the P13K pathway and induce G(1) arrest. NPV-BEZ235 has been shown to inhibit VEGF induced cell proliferation and survival in vitro and VEGF induced angiogenesis in vivo. It has also been shown to inhibit the growth of human cancer in animal models.

     

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  13. BI2536
    BI2536
    $150.00

    BI2536 is a small molecule inhibitor of Polo Like Kinase 1 (PLK1). PLK1 is a serine/threonine protein kinase and is a key regulator of multiple processes essential to mitosis and cell division. Inhibition of PLK1 by BI2536 results in mitotic arrest, disruption of cytokinesis and apoptosis in tumor cell populations.  BI2536 has been shown to inhibit growth of xenographs in nude mice and induces regression of large tumors with well tolerated intravenous dose regimens.

     

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  14. BIBW-2992
    BIBW-2992
    $89.00

    BIBW-2992 is a irreversible and dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) kinases.  The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed. BIBW-2992 has also been shown to suppress EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines.

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  15. BIO
    BIO
    $79.00

    BIO is a potent, reversible and ATP-competitive inhibitor of GSK3α/β.  The inhibition of  GSK by BIO has been shown to activate the Wnt signaling pathway  and sustain pluripotency in murine and human embryonic stem cells. BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. It has also been shown to induce the differentiation of neonatal cardiomyocytes.

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  16. BIX01294
    BIX01294
    $99.00

    BIX01294 is a histone lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. It selectively inhibits the G9a HMTase and the generation of histone H3 lysine 9 methylation. BIX01294, when used in combination with HDAC inhibitor Valproic Acid has been used as a replacement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. BIX01294 is a useful for the study of histone lysine methylation, differentiation and reprogramming. 

     

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  17. Brefeldin A
    Brefeldin A
    $54.00

    Brefeldin A (BFA) (IC50 value of 0.2 μM) is an inhibitor of ATPase. ATPase is a chemical enzyme. It is essential in the ADP/ATP exchange providing chemical potential energy. ATP supplies the energy for such physiological activities such as importing metabolites necessary for cell metabolism, exporting toxins, wastes, and solutes that can hinder cellular processes, cell proliferation, ER stress and so forth. When tested with cell line HEK293 cells (stably express wild-type (wt) CRELD2), BFA treatment nearly abolished the secretion of wtCRELD2 completely via inhibiting the transportation of proteins from the ER to the Golgi apparatus [4]. In MCF-7 cells and Hela cells, treatment with BFA induced p53 expression via inhibiting ATP which enhanced ER stress [5]. When treated with colorectal cancer cell line HCT116 cells, BFA treatment induced cells apoprosis by inhibiting ATP which functioned in the process of cellular vesicle trafficking Treatment with BFA could attenuate stimulus-dependent hyperalgesia phenomenon via inhibiting vesicular exocytosis which process is important for ATP release. BFA also is reported as an inhibitor for GTP/GDP exchange in a dose-dependent way, which is important in vesicular trafficking. Learn More
  18. BX-795
    BX-795
    $84.00

    BX-795 is a potent inhibitor of both PDK1 and TBK1 as well as IKKε.  It acts by blocking phosphorylation and is reversible. Learn More
  19. CH5424802
    CH5424802
    $180.00

    CH5424802, also known as AF802, is a potent and selective Anaplastic lymphoma kinase (ALK) inhibitor. ALK is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mutation. It has shown limited inhibition of other kinases, GAK and LTK. LTK is known to show greatest sequence similarity to ALK. Learn More
  20. CHIR99021 Structure
    CHIR99021

    Regular Price: $219.00

    Special Price: $84.00

    CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β (GSK3β). CHIR99021 does not show cross-reactivity against cyclin-dependent kinases (CDKs) with a 350 fold selectivity toward GSK3β compared to CDKs with a Kᵢ of <10nM in vitro. CHIR99021 has been shown in long term expansion of murine embryonic stem cells in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Learn More
  21. CI-994
    CI-994
    $75.00

    CI-994 is a histone deacetylase (HDAC) inhibitor that induces hyperacetylation in living cells.  CI-994 mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.  CI-994 originally was developed as an anticonvulsant agent and later was reported to have antitumor activity.

     

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  22. Ciglitazone
    Ciglitazone
    $90.00

    Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class, selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). It activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo. Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Learn More
  23. CP690550
    CP690550
    $99.00

    CP690550 is a novel Janus kinase 3 (JAK3) inhibitor. JAK3 is a critical cytoplasmic tyrosine kinase in the signaling pathways of multiple cytokines associated with T cell function.  CP690550 displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring JAK2(V617F) compared with JAK2(WT). 

     

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  24. Crizotinib
    Crizotinib
    $129.00

    Crizotinib is a potent ATP competitive inhibitor of c-MET and anaplastic lymphoma kinase (ALK). It has been shown to display antitumor efficacy in multiple tumor models and has been shown to inhibit c-MET dependent proliferation, migration and invasion of tumor cells in vitro. Crizotinib is selective for c-MET and ALK against over 120 different kinases. 

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  25. Cyclopamine
    Cyclopamine
    $199.00

    Cyclopamine is a small molecule inhibitor of the sonic hedgehog pathway (Hh) by binding to the heptahelical bundle of Smoothened. It inhibits the growth of medulloblastoma cells. Hedgehog signaling is involved in embryogenesis as well as cancer progression. It is a steroid alkaloid  and originally identified as a teratogenic agent.

     

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  26. Dacomitinib
    Dacomitinib
    $199.00

    Dacomitinib, also known as PF-00299804, is a second-generation irreversible pan-erbB (HER) receptor tyrosine kinase inhibitor.  It is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members.  The HER family of tyrosine kinases included receptors HER-1 (EGFR), HER-2,3 and 4.  The HER signaling pathway plays a role in the normal regulation of cell growth and proliferation, differentiation, and apoptosis.  Activation of HER receptors drives signal transduction pathways; dysregulated signaling through the HER receptors may lead to malignant transformation and growth. Learn More
  27. Daidzin
    Daidzin
    $39.00

    Daidzin is a glucoside of the isoflavone daidzein found in soy beans. It demonstrates chemopreventive activities by inhibiting the bioactivation of carcinogenic arylamines. It is also a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Learn More
  28. DAPT
    DAPT
    $89.00

    DAPT is a γ-secretase inhibitor that indirectly inhibits Notch, a γ-secretase substrate. Since Notch is involved in the development of the nervous system and pancreas, DAPT has been suggested to be used in the modulation of Notch activity in embryonic stem cell differentiation. As an inhibitor of γ-secretase, DAPT may also be useful in the study of β-amyloid (Aβ) formation.

     

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  29. Dexamethasone
    Dexamethasone
    $35.00

    Dexamethasone, a synthetic glucocorticoid with a higher affinity than a natural ligand, cortisol, has a range of effects on cell survival, cell signaling and gene expression. It is know to affect inflammatory responses, cellular proliferation, and differentiation in target tissues. Dexamethasone has been shown to inhibit differentiation of cord blood stem cell derived dendritic cells (DC) precusors into immature DCs. Learn More
  30. Dorsomorphin Chemical Structure
    Dorsomorphin

    Regular Price: $99.00

    Special Price: $59.00

    Dorsomorphin (also known as Compound C) is a potent, reversible, AMPK inhibitor with Ki of 109 NM in the absence of AMP. In addition, it has been found to selectively inhibit bone morphogenetic protein (BMP) signaling. Learn More
  31. Dovitinib
    Dovitinib
    $99.00

    Dovitinib is a small molecule receptor tyrosine kinase inhibitor. It potently inhibits receptor tyrosine kinases including FLT3, c-KIT, CSF-1R/c-fms, FGFR1, FGFR3, VEGFR1/Flt1,VEGFR2/Flk1, VEGFR3/Flt4, PDGFRβ, and PDGFRα. Dovitinib shows both antitumor and antiangiogenic activities in vivo. It has also been used as an  effective treatment in xenograft mouse models of FGFR3 multiple myeloma (MM).  

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  32. EHNA Hydrochloride
    EHNA Hydrochloride
    $69.00

    EHNA Hydrochloride is a reversible adenosine deaminase inhibitor that selectively inhibits the cGMP-specific phosphodieterase (PDE2). At a 10µM concentration, EHNA has been shown to effectively and reversibly block the differentiation and maintain the pluripotency of the hES cell line SA121 in feeder- free cultures without exogenously added FGF for up to 30 passages. EHNA has also been used to study the cardioprotective and neuroprotective efforts during ischemia and in the study of cAMP/cGMP signaling.

     

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  33. Enzastaurin
    Enzastaurin
    $99.00

    Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively. It has a direct effect on human tumor cells by inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay and decreases microvessel density. It also prevents VEGF secretion from human tumor cell xenographs in nude mice. Prolonged courses of Enzastaurin increases chemotherapy or radiation tumor growth delay of breast, glioma and small cell lung cancer xenographs.

     

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  34. Everolimus
    Everolimus
    $114.00

    Everolimus inhibits mTOR (mammalian target of rapamycin), a serine-threonine kinase, by binding with high affinity to the FK506 binding protein-12 (FKBP-12) thus inducing cell growth arrest and apoptosis. It is chemically very similar to Rapamycin. It is also used to prevent rejection of organ transplants. Learn More
  35. Fludarabine
    Fludarabine
    $55.00

    Fludarabine, also known as Fludara, F-ara-A, and NSC 118218, is a purine antimetabolite. It's activity occurs as the result of activation to 2-fluoro-ara-ATP and includes inhibition of DNA synthesis primarily in the S-phase of cell division by inhibition of ribonucleotide reductase and the DNA polymerases. It is also postulated that fludarabine interferes with RNA by decreased incorporation of uridine and leucine into RNA and protein, respectively. Fludarabine is also active against non-proliferating cells. Learn More
  36. Forskolin
    Forskolin
    $119.00

    Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes.  Forskolin has also been shown to effect calcium currents and inhibit MAP kinase.

     

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  37. FTY720
    FTY720
    $69.00

    FTY720 is a potent sphingosine-1-phosphate (S1P) receptors agonist that reverses the effects of BCR-ABL kinase.  It is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5.) FTY720 is a novel immunomodulating agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.

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  38. G418
    G418
    $39.00

    Geneticin Sulfate, also known as G418, is an aminoglycoside antibiotic. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that G418 inhibits the incorporation of amino acids into protein and can destroy fibroblasts. G418 is toxic to bacteria, yeast, higher plants, mammalian cells, protozoans and helminths. In mammalian cells, selection is commonly performed using 400 mg/L G418, followed by 200 mg/L for culture maintenance. G418 is commonly used for the selection of cells that are genetically engineered with a plasmid containing the neo (neor) gene, which provides resistance to G418. This antibiotic is commonly used during the selection of transfected cell lines. Learn More
  39. GANT 61
    GANT 61
    $99.00

    GANT 61 is a GLI antagonist. It inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GL1 nuclear accumulation. GANT 61 has been shown to inhibit proliferation of PANC1 and 22Rv1 cancer cells in vitro. In Vivo, it has displayed display antiproliferative effects and antitumor activity. GANT 61 has also been shown to block cell growth in vivo xenograft models using human prostate cancer cells.

     

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  40. GDC0449 (Vismodegib)
    GDC0449 (Vismodegib)
    $99.00

    GDC0449 is a potent hedgehog (Hh) signaling pathway inhibitor with an IC₅₀ of 3nM.  The Hedgehog signaling pathway plays an important role in tissue growth and repair. GDC0449 works by blocking the activities of the Hedgehog-ligand cell surface receptors PTCH or SMO and suppresses Hedgehog signaling. It has been shown to inhibit the growth of primary pancreatic xenographs without non-specifically inhibiting pancreatic cell proliferation in vitro. GDC0449 has also been shown to inhibit ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. It has also been used to treat medullablastoma in animal models.

     

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  41. GDC0941
    GDC0941
    $99.00

    GDC0941 is a phosphatidylinositol 3-kinase (P13K) inhibitor. GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50's of 0.003 µM (P110α), 0.033 µM (P110β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK).

     

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  42. Genistein
    Genistein
    $44.00

    Genistein is a naturally occurring isoflavone found mainly in soy products. It inhibits protein tyrosine kinase and topoisomerase-II as well as angiogenesis. It has been shown to be involved in regulating apoptosis, an important target in cancer research. Learn More
  43. GW788388
    GW788388
    $90.00

    GW788388 is a selective inhibitor of transforming growth factor-beta type I (TGF-betaI) receptor (activin receptor-like kinase 5 (ALK5)). It is know to inhibit esophageal squamous cell carcinoma induced neoangiogenisis. Learn More
  44. HA-1077 (dihydrochloride)
    HA-1077 (dihydrochloride)
    $99.00

    HA-1077 is a potent inhibitor of Rho-associated kinase II (ROCK-II), and also inhibits Protein Kinase C-related kinase 2 (PRK2),  Mitogen- and Stress-Activated Protein Kinase (MSK1), and Mitogen Activated Protein Kinase-Activated Protein Kinase 1b (MAPKAP-K1b). HA-1077 is a novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. Through the inhibition of Rho-kinase, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in rodent models.

     

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  45. Honokiol
    Honokiol
    $109.00

    Honokiol is a biologically active constituent of oriental medicinal herb Magnolia officinalis/grandiflora. It displays anxiolytic, antithrombotic, anti-tumor properties.  In addition it modulates the NF-κB activation pathway, an upstream effector VEGF, COX-2, and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. Learn More
  46. INCB-018424
    INCB-018424
    $150.00

    INCB-018424, also known as Ruxolitinib, is a potent and selective inhibitor of Janus -associated kinase 1 and 2 (JAK1,2). It acts by blocking the JAK/STAT pathway. It is also shown to selectively inhibit a wide range of other kinases including JAK3. Learn More
  47. Indolactam V
    Indolactam V
    $299.00

    Indolactam V is an activator of protein kinase C (PKC) that works by inhibiting PKC isozymes (alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta). This inducing differentiation in embryonic stem cells into pancreatic progenitors. It also exhibits tumor promoting activity. Learn More
  48. Iniparib
    Iniparib
    $99.00

    Iniparib is a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP1). PARP1 has been shown to play an important role in the repair of naturally occurring DNA damage in cells and in DNA that has been damaged by chemotherapy.  Iniparib has demonstrated activity in multiple types of solid tumors, with prolonged inhibition of its target.

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  49. IPA3
    IPA3
    $75.00

    IPA3 is a selective inhibitor of P21-activated kinase (PAK1). It functions by targeting the autoregulatroy mechanism, inhibiting the activators from binding to the active sites on the enzyme, producing the inactive conformation of PAKs. The autoinhibitory regions suppress the catalytic activity of its kinase domain, which are removed once activators have bound to the protein. IPA2 does not inhibit PAK1 if activators are already bound to the enzyme. PAK1 is implicated in tumorigenisis and metastasis. Learn More
  50. IWP-2
    IWP-2
    $99.00

    IWP-2 is an inhibitor of Wnt production and an inactivator of Porcn function.  The Wnt/b-catenin pathway maintains transcriptional programs that enable stem cells to remain multipotent and hyperactivation of this pathway leads to disease stage. IWP-2 inactivates Porcn function by either directly inhibiting the Porcn active site or by modulating the function of the Porcn regulator.

     

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