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A83-01

2 mg

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Cat No. 63-A05

Availability: In stock

$99.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

A83-01 is a TGFβ kinase/activin receptor like kinase (ALK5) inhibitor. It blocks the phosphorylation of Smad2 and inhibits TGFβ-induced epithelial-to-mesenchymal transition. A83-01 is more potent than small molecule SB431542, and has been shown to inhibit differentiation of rat induced pluripotent stem cells (iPSCs) and increases clonal expansion efficiency. Small molecule A83-01 helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.


 

A83-01

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TECHNICAL INFORMATION

Other Names: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Chemical Formula: C25H19N5S

CAS Number: 909910-43-6

Molecular Weight: 421.52

Purity:  ≥98% by HPLC

Appearance: Pale Yellow Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO to 100mM.  For a 10mM concentrated stock solution, reconstitute the compound by adding 475ul of DMSO to the entire contents of the vial. Incubate in a 37°C water bath for 5 minutes if precipitate is observed. For most cells, the maximum tolerance to DMSO is <0.5%.

 

 

 

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