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AT13387

5mg

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Cat No. 81-D36

Availability: In stock

$280.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

AT13387 is a synthetic, small-molecule inhibitor of heat shock protein 90 (Hsp90). It selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.

AT13387

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TECHNICAL INFORMATION

Other Names: (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone

Chemical Formula: C24H31N3O3

CAS Number: 912999-49-6

Molecular Weight: 409.52

Purity: >99%

IC50= 18nM

Appearance: White Powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

 

References

 

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