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Bafilomycin A1

1 MG

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Cat No. 24-R68

Availability: In stock

$135.00

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Description

Bafilomycin A1 is a macrolide antibiotic that selectively inhibits vacuolar-type (v-type) H+ ATPase. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, E. coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. It blocks pH regulation in brain cells. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases.

Bafilomycin A1

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TECHNICAL INFORMATION

Other Names: (3Z, 5E, 7R, 8S, 9S, 11E, 13E, 15S, 16R)-8-hydroxy-16-[(1S, 2R, 3S)-2-hydroxy-1-methyl-3-[(2R, 4R, 5S, 6R)-tetrahydro-2, 4-dihydroxy-5-methyl-6-(1-methlethyl)-2H-pyran-2-yl]butyl]-3, 15-dimethoxy-5, 7, 9, 11-tetramethyl-oxacyclohexadeca-3, 5, 11, 13-tetraen-2-one

Chemical Formula: C35H58O9

CAS Number: 88899-55-2

Molecular Weight: 622.83

Purity: >98%

IC50= 0.6-1.5nM

Appearance: Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

 

References

 

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