Other Names: Afatinib
Chemical Formula: C24H25ClFN5O3
CAS Number: 850140-72-6
Molecular Weight: 485.94
Appearance: a crystalline solid
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO at 200 mg/ml. Soluble in ethanol at 25mg/ml. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.
Takezawa et al. (2010) Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther. 9(6):1647-56.