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Crizotinib

5 mg

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Cat No. 61-V83

Availability: In stock

$129.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Crizotinib is a potent ATP competitive inhibitor of c-MET and anaplastic lymphoma kinase (ALK). It has been shown to display antitumor efficacy in multiple tumor models and has been shown to inhibit c-MET dependent proliferation, migration and invasion of tumor cells in vitro. Crizotinib is selective for c-MET and ALK against over 120 different kinases. 

Crizotinib

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TECHNICAL INFORMATION

Other Names: PF-02341066, PF-1066, PF-2341066

Chemical Formula:  C21H22Cl2FN5O

CAS Number: 877399-52-5

Molecular Weight: 450.34

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 25 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

References

 

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