Other Names: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Chemical Formula: C23H27N7O3S2
CAS Number: 957054-30-7
Molecular Weight: 513.64
Appearance: a crystalline solid
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO at 66mg/ml. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.
Folkes et al. (2008) The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 51(18):5522-32.
Raynaud et al. (2009) Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 8(7):1725-38.