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INCB-018424

5 mg

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Cat No. 28-R52

Availability: In stock

$150.00

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Description

INCB-018424, also known as Ruxolitinib, is a potent and selective inhibitor of Janus -associated kinase 1 and 2 (JAK1,2). It acts by blocking the JAK/STAT pathway. It is also shown to selectively inhibit a wide range of other kinases including JAK3.

INCB-018424

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TECHNICAL INFORMATION

Other Names: β-Cyclopentyl-4-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-(βR)-1H-pyrazole-1-propanenitrile

Chemical Formula: C17H18N6

CAS Number: 941678-49-5

Molecular Weight: 306.37

Purity: >99%

IC50= JAK1 3nM, JAK2 5nM, JAK3 332nM

Appearance: Pale Yellow Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

 

References

 

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