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Masitinib (AB1010)

10 mg

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Cat No. 26-A39

Availability: In stock

$99.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Masitinib (AB1010) is a protein tyrosine kinase inhibitor. It targets c-KIT, PDGFR and FGFR3.  It also potently inhibits human and murine KIT with activating mutations in the juxtamembrane domain. In vivo, Masitinib  has been shown to block tumor growth in mice with subcutaneous grafts of Ba/F3 cells expressing a juxtamembrane KIT mutant.


 

Masitinib (AB1010)

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TECHNICAL INFORMATION

Other Names: AB1010, Masitinib mesylate

Chemical Formula:  C28H30N6OS

CAS Number: 790299-79-5

Molecular Weight: 498.64

Purity:  >99%

Appearance:  crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 200mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

 

References

 

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