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Neratinib

5 mg

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Cat No. 50-P44

Availability: In stock

$149.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Neratinib, also known as HKI-272, is a second-generation inhibitor of the ErbB family of receptor kinases. Neratinib is an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor.  Neratinib has been shown to inhibit the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro. In vivo, Neratinib has been shown to be active against HER-2- and EGFR-dependent tumor xenograft models .


 

Neratinib

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TECHNICAL INFORMATION

Other Names: HKI-272

Chemical Formula: C30H29ClN6O3

CAS Number: 698387-09-6

Molecular Weight: 557.04

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 2 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

 

References

 

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