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NSC74589

5mg

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Cat No. 18-N27

Availability: In stock

$65.00

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Description

NSC74859, also known as S3I-201, binds the Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription, therefore, inhibiting growth and inducing apoptosis preferentially in tumor cells that contain persistently activated Stat3. Moreover, NSC74859 also inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin.

NSC74589

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TECHNICAL INFORMATION

Other Names: 2-hydroxy-4(2-(tosyloxy)acetamido)benzoic acid

Chemical Formula: C16H15NO7S

CAS Number: 501919-59-1

Molecular Weight: 365.36

Purity: >98%

IC50= 86┬ÁM

Appearance: Light Beige Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 73mg/ml

 

References

 

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