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Sorafenib

5mg

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Cat No. 13-D24

Availability: In stock

$99.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Sorafenib, also known as Nexavar, is a small molecule inhibitor of several tyrosine protein kinases, VEGFR 2 & 3 as well as PDGFR, and RAF/MEK/ERK cascade inhibitor. It also inhibits c-Kit, the ligand for Stem cell factor. It does not significantly inhibit MEK-1 or ERK-1 activity. It interacts in combination with the proteasome inhibitor bortezomib to induce apoptosis in a broad spectrum of neoplastic cell lines.

NOTE: The small molecule Sorafenib sold by Reagents Direct is NOT Nexavar®, and is NOT for human use.


Sorafenib

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TECHNICAL INFORMATION

Other Names: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamine

Chemical Formula: C14H16CIF3N4O3

CAS Number: 284461-73-0

Molecular Weight: 464.82

Purity: >99%

IC50= 6nM

Appearance: Light Yellow Powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

 

References

 

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