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Tranylcypromine

50mg

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Cat No. 65-L28

Availability: In stock

$25.00

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Description

Tranylcypromine hydrochloride , also known as 2-PCPA, is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110), a histone demethylase, and non-hydrazine monoamine oxidases (MAO). Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, ubiquitination, methylation, and sumoylation to produce a specific gene regulatory outcome. Complementary enzymes catalyze the addition and removal of these modifications as needed. The amine oxidase domain-containing enzyme lysine-specific demethylase 1 (LSD1) is a part of one of two classes of histone demethylases capable of demethylating lysine residues. LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B. Treatment of P19 embryonal carcinoma cells with tranylcypromine resulted in global increase in H3K4 methylation as well as transcriptional derepression of the pluripotent stem cell marker Oct43.

Tranylcypromine

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TECHNICAL INFORMATION

Other Names: (1R, 2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride

Chemical Formula: C9H11N-HCL

CAS Number: 1986-47-6

Molecular Weight: 169.65

Purity: >98%

IC50= MAO A: 2.3μM MAO: .95μM

Appearance: Crystalline Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO

 

References

 

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