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Cyclopamine

5 mg

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Cat No. 29-O52

Availability: In stock

$199.00

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Description

Cyclopamine is a small molecule inhibitor of the sonic hedgehog pathway (Hh) by binding to the heptahelical bundle of Smoothened. It inhibits the growth of medulloblastoma cells. Hedgehog signaling is involved in embryogenesis as well as cancer progression. It is a steroid alkaloid  and originally identified as a teratogenic agent.


 

Cyclopamine

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TECHNICAL INFORMATION

Other Names: 11-deoxojervine (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5'; octadecahydro-3',6',10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

Chemical Formula:  C27H41NO2

CAS Number: 4449-51-8

Molecular Weight: 411.62

Purity:  >99%

Appearance: Off white solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10 mM concentrated stock solution, reconstitute the compound by adding 486 μl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.

 

 

References

 

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