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Dacomitinib

5mg

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Cat No. 21-Q15

Availability: In stock

$199.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Dacomitinib, also known as PF-00299804, is a second-generation irreversible pan-erbB (HER) receptor tyrosine kinase inhibitor.  It is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members.  The HER family of tyrosine kinases included receptors HER-1 (EGFR), HER-2,3 and 4.  The HER signaling pathway plays a role in the normal regulation of cell growth and proliferation, differentiation, and apoptosis.  Activation of HER receptors drives signal transduction pathways; dysregulated signaling through the HER receptors may lead to malignant transformation and growth.

Dacomitinib

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TECHNICAL INFORMATION

Other Names: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide

Chemical Formula: C24H25CIFN5O2

CAS Number: 1110813-31-4

Molecular Weight: 469.94

Purity: >98%

IC50= HER-1: 6nM, HER-2: 45.7nM, HER-4: 73.7nM

Appearance: White Powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 21mg/ml

 

References

 

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