Other Names: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
Chemical Formula: C24H25CIFN5O2
CAS Number: 1110813-31-4
Molecular Weight: 469.94
IC50= HER-1: 6nM, HER-2: 45.7nM, HER-4: 73.7nM
Appearance: White Powder
Solubility: DMSO (100mM)
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO. Soluble at 21mg/ml
Takahashi, T., et al (2012). Phase 1 and pharmacokinetic study of Dacomitinib (PH-00299804), an oral irreversible, small molecule inhibitor of human epidermal growth factor receptor –1, -2 and –4 tyrosine kinases, in Japanese patients with advanced solid tumors. Invest new Drugs.
Ramalingam, S.S., et al (2012). Randomized phase II study of Dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. J. Din. Oncol.