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Everolimus

10 mg

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Cat No. 55-X21

Availability: In stock

$114.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Everolimus inhibits mTOR (mammalian target of rapamycin), a serine-threonine kinase, by binding with high affinity to the FK506 binding protein-12 (FKBP-12) thus inducing cell growth arrest and apoptosis. It is chemically very similar to Rapamycin. It is also used to prevent rejection of organ transplants.

Everolimus

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TECHNICAL INFORMATION

Other Names: 40-O-(2-Hydroxyethylrapamycin)

Chemical Formula: C53H83NO14

CAS Number: 159351-69-6

Molecular Weight: 958.22

Purity: >99%

IC50= .63nM (mTOR)

Appearance: Off white solid powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

 

References

 

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