Other Names: Faridak, Panobinostat, NVP-LBH-589
Chemical Formula: C21H23N3O2
CAS Number: 404950-80-7
Molecular Weight: 349.43
Appearance: a crystalline solid
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO at 200 mg/ml. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.
George et al. (2005) Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood. 105(4):1768-76.
Vilas-Zornoza et al. (2012) Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia. Leukemia. Feb 6. doi: 10.1038/leu.2012.31.