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Rapamycin

5 mg

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Cat No. 33-U72

Availability: In stock

$129.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex1 (mTORC1).  It is a potent immunosuppressant and has shown anticancer activity. Rapamycin It has a variety of uses both in vitro and in vivo and has been used to prevent organ rejection after transplantation. 

Rapamycin

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TECHNICAL INFORMATION

Other Names: AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A

Chemical Formula: C51H79NO13

CAS Number: 53123-88-9

Molecular Weight: 914.17

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 50 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

 

References

 

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