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SAHA (Vorinostat)

100 mg

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Cat No. 31-V28

Availability: In stock

$99.00

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Description

SAHA (Vorinostat) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme and blocks substrate access. It inhibits class I and class II HDACs at around 50nM. SAHA has been shown to cause growth arrest and death of some transformed cells both in vitro and in vivo, with little or no toxic effects on normal cells. 


 

SAHA (Vorinostat)

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TECHNICAL INFORMATION

Other Names: SAHA, Vorinostat, MK-0683,  Suberoylanilide Hydroxamic Acid, Suberanilohydroxamic Acid , Zolinza

Chemical Formula:  C14H20N2O3

CAS Number: 149647-78-9

Molecular Weight: 264.32

Purity:  >99%

Appearance:  crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 66mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

 

References

 

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