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Saracatinib

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  1. Saracatinib (AZD0530)
    Saracatinib (AZD0530)
    $99.00

    Saracatinib is a highly selective, orally available Src/Abl kinase inhibitor.  It is highly selective for Src and Abl kinases against a large range of tyrosine and serine-threonine kinases (VEGFR, FGFR, c-Kit etc,) Saracatinib exerts its activity through ATP competitive and reversible inhibition  of the target enzyme. Saracatinib has been shown to inhibit tumor growth in a manner independent of dose and inhibits phosphorylation of focal adhesion kinase (FAK) and paxillin in a dose-dependent manner in a Calu-6 Xenograft model.

     

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