Reagents Direct

direct results now

Skip to Main Content »

Your shopping cart is empty

Selumetinib

5mg

Be the first to review this product

Cat No. 07-V75

Availability: In stock

$89.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

OR

Description

Selumetinib, also known as AZD6244, is a potent inhibitor of MAPK/ERK kinase 1/2. It is not competitive with ATP and inactivates the ERK1/2 phosphorylation. This is important because these kinases lie downstream to BFAF and RAGS genes. The effect of mutation in these genes is controlled by inhibiting the kinases downstream.

Selumetinib

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Details

TECHNICAL INFORMATION

Other Names: 5-[(-bromo-2-chlorophenyl)amino]-4-fluoro-Nl-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Chemical Formula: C17H15CIFN4O3

CAS Number: 606143-52-6

Molecular Weight: 457.68

Purity: >99%

IC50= 14 nM

Appearance: Crystalline Solid

Solubility: DMSO (92mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 92mg/ml

 

References

 

Tech Docs