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Tozasertib

25 mg

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Cat No. 11-W09

Availability: In stock

$59.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Tozasertib is a potent inhibitor of all aurora kinases, including isotypes A, B and C. It has been shown to inhibit cell cycle progression, induce apoptosis and block tumor growth in varieties of in vivo xenograft models. Tozasertib has been shown to cause accumulation of cells with 4N DNA content and potently inhibit the proliferation of a wide variety of tumor cell types with IC50 values ranging from 15 to 113 nM. Tozasertib had no effect on the viability of noncycling primary human cells at concentrations as high as 10uM.


 

Tozasertib

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TECHNICAL INFORMATION

Other Names: VX-680, MK-0457, VX6

Chemical Formula: C23H28N8OS

CAS Number: 639089-54-6

Molecular Weight: 464.49

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 100 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

References

 

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