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Troglitazone

5mg

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Cat No. 05-E10

Availability: In stock

$59.00

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Description

Troglitazone is a potent antiproliferative and apoptosis inducer and is a selective PPARγ agonist. There was no activation of PPARα and PPARδ observed at concentrations up to 10 µM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 µM

Troglitazone

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TECHNICAL INFORMATION

Other Names: 5-[[4-[(3,4-dihydro-6-hydroxy-2, 5, 7, 8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazlidinedione

Chemical Formula: C24H27NO5S

CAS Number: 97322-87-7

Molecular Weight: 441.5

Purity: >98%

IC50= 10 μm

Appearance: Yellow Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 25mg/ml

 

References

 

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