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Wortmannin

1 mg

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Cat No. 49-U91

Availability: In stock

$49.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (P13K) inhibitor. Inhibitor of the P13K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Wortmannin has been shown to block many of the short-term metabolic effects induced by insulin receptor activation by the inhibition of P13K.


 

Wortmannin

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TECHNICAL INFORMATION

Other Names: (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione, SL-2052

Chemical Formula:  C23H24O8

CAS Number: 19545-26-7

Molecular Weight: 428.44

Purity:  >98%

Appearance: solid powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO to 10 mM. Note: for most cells, the maximum tolerance to DMSO is <0.5%. If a precipitate is observed, vortex for 5 minutes.

 

References

 

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