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ZM447439

5mg

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Cat No. 94-U12

Availability: In stock

$99.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

ZM447439 is a selective ATP-competitive inhibitor of Aurora B kinase. The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.

ZM447439

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TECHNICAL INFORMATION

Other Names: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide

Chemical Formula: C29H31N5O4

CAS Number: 331771-20-1

Molecular Weight: 513.6

Purity: >99%

IC50= Aurora B: 50nM, Aurora C and A: 250 &1,000nM, CDK1, CDK2, CDK4, PLK1, CHK1, KDR2 & FAK: 10┬ÁM

Appearance: Off-White Crystalline Solid

Solubility: DMSO (25mg/ml)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 25mg/ml

 

References

 

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