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Anacardic Acid

5 mg

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Cat No. 08-N16

Availability: In stock

$89.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Anacardic acid is a histone acetyltransferase (HAT) inhibitor. It inhibits the HAT activity of the transcription co-activators p300 and p300/CREB-biding protein associated factor (pCAF) with IC50 values of 8.5 and 5 µM. It has been shown to display a variety of biological activities, including antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition. Anacardic acid has been shown to decrease expression of NF-κB regulated gene products including, invasion, inflammation, proliferation and cell survival. It has also been linked to be a potent activator of Aurora Kinase A (ARK-1) mediated phosphorylation of histone H3.

Anacardic Acid

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TECHNICAL INFORMATION

Other Names: 6-pentadecyl Salicylic Acid, 2-​hydroxy-​6-​pentadecyl-​benzoic acid

Chemical Formula: C22H36O3

CAS Number: 16611-84-0

Molecular Weight: 348.5

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

References

 

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