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BIO

2 mg

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Cat No. 45-H38

Availability: In stock

$79.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

BIO is a potent, reversible and ATP-competitive inhibitor of GSK3α/β.  The inhibition of  GSK by BIO has been shown to activate the Wnt signaling pathway  and sustain pluripotency in murine and human embryonic stem cells. BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. It has also been shown to induce the differentiation of neonatal cardiomyocytes.

BIO

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TECHNICAL INFORMATION

Other Names: GSK 3 IX, MLS 2052, 6-​bromo-​3-​[(3E)-​1,​3-​dihydro-​3-​(hydroxyimino)-​2H-​indol-​2-​ylidene]-​1,​3-​dihydro-​(3Z)-​2H-​indol-​2-​one

Chemical Formula:  C16H10BrN3O2

CAS Number: 667463-62-9

Molecular Weight: 356.2

Purity:  >98%

Appearance:  a crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10 mM concentrated stock solution, reconstitute the compound by adding 561.5 µl of DMSO to the entire contents of the vial. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

 

References

 

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