Other Names: GSK 3 IX, MLS 2052, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-(3Z)-2H-indol-2-one
Chemical Formula: C16H10BrN3O2
CAS Number: 667463-62-9
Molecular Weight: 356.2
Appearance: a crystalline solid
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO. For a 10 mM concentrated stock solution, reconstitute the compound by adding 561.5 µl of DMSO to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.
Polychronopoulous et al. (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 47(4):935-46.