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BIX01294

5 mg

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Cat No. 74-O89

Availability: In stock

$99.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

BIX01294 is a histone lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. It selectively inhibits the G9a HMTase and the generation of histone H3 lysine 9 methylation. BIX01294, when used in combination with HDAC inhibitor Valproic Acid has been used as a replacement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. BIX01294 is a useful for the study of histone lysine methylation, differentiation and reprogramming. 


 

BIX01294

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TECHNICAL INFORMATION

Other Names: 2-(Hexahydro-4-methyl-1H-1,4-diazep
in-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piper
idinyl]-4-quinazolinamine trihydrochloride

Chemical Formula:  C28H38N6O2.3HCl 

CAS Number: 935693-62-2

Molecular Weight: 600.02

Purity:  >99%

Appearance:  white solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, reconstitute the compound in 1.02ml of DMSO to the entire contents of the vial. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

 

References

 

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