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PD0325901

2 mg

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Cat No. 39-C68

Availability: In stock

Regular Price: $219.00

Special Price: $84.00

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Description

PD0325901 is an organic molecule targeting mitogen– activated protein kinase (MAPK/ERK kinase or MEK). PD0325901 is a derivative of MEK inhibitor CI-1040 and selectively binds to and inhibits MEK which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation.  In combination with CHIR99021, PD0325901 has been shown to prevent cell differentiation and sustain ES cell self-renewal.


 

PD0325901

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Details

TECHNICAL INFORMATION

Other Names: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide

Chemical Formula: C16H14F3IN2O4

CAS Number: 391210-10-9

Molecular Weight: 482.19

Purity: 99.7% by HPLC

Appearance: Off-white solid

Solubility: DMSO (20 mg/ml) or EtOH (20 mg/ml)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 415 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.  Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

When used in combination with CHIR99021, PD0325901 has been shown to sustain ES cell self-renewal.

 

References

 

Tech Docs

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