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Ciglitazone

5mg

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Cat No. 48-A90

Availability: In stock

$90.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class, selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). It activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo. Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.

Ciglitazone

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TECHNICAL INFORMATION

Other Names: 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2, 4-thiazolidinedione

Chemical Formula: C18H23NO3S

CAS Number: 74772-77-3

Molecular Weight: 333.50

Purity: >98%

IC50= 3 µM

Appearance: Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 25mg/ml

 

References

 

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