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LY294002

5 mg

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Cat No. 89-Y31

Availability: In stock

$79.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

LY294002 is a cell permeable, selective phosphatidylinositol 3-kinase (P13K) inhibitor that acts as a competitor inhibitor of the ATP binding site of the enzyme. LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mESC’s LY294002 prevents self-renewal by inhibiting LIF2. LY294002 does not affect the activities of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase and c-Src even at 50µl. LY294002 has also been shown to be an inhibitor of casein kinase II.

LY294002

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TECHNICAL INFORMATION

Other Names: 2-​(4-​morpholinyl)-​8-​phenyl-​4H-​1-​benzopyran-​4-​one

Chemical Formula: C19H17NO3

CAS Number: 154447-36-6

Molecular Weight: 307.3

Purity:  >98%

Appearance: Off White Crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, reconstitute the compound by adding 1627µl to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells the maximum tolerance to DMSO is <0.5%.   

 

 

References

 

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