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RO4929097

2 mg

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Cat No. 80-Y15

Availability: In stock

$169.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

RO4929097 is a small molecule gamma secretase inhibitor with an IC₅₀ of 4nM. It binds to gamma secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.

RO4929097

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TECHNICAL INFORMATION

Other Names: RO-4929097

Chemical Formula:  C22H20F5N3O3

CAS Number: 847925-91-1

Molecular Weight: 469.4

Purity:  >99%

Appearance:  white solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. If precipitate is observed,  vortex for 5 minutes.

 

 

References

 

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