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Trichostatin A (TSA)

1 mg

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Cat No. 62-K44

Availability: In stock

$79.00

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Description

Trichostatin A is a selective and potent inhibitor of histone deacetylase (HDAC). It selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, resulting in chromatin relaxation and modulation of gene expression. Trichostatin A has been shown to inhibit both the G1- and G2– phases of the mammalian cell cycle and has been used to induce apoptosis in cancer cells with low toxicity to non-cancer cells.

Trichostatin A (TSA)

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TECHNICAL INFORMATION

Other Names: TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Chemical Formula: C17H22N2O3

CAS Number: 58880-19-6

Molecular Weight: 302.37

Purity: ≥98%

Appearance: Crystalline solid

Solubility: Ethanol

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in ethanol. For a 4mM stock solution, reconstitute the compound by adding 826uL of ethanol.

 

 

References

 

Tech Docs

Spec Sheet

Certificates of Analysis

MSDS