Reagents Direct

direct results now

Skip to Main Content »

Your shopping cart is empty

U0126

5 mg

Be the first to review this product

Cat No. 84-P22

Availability: In stock

$99.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

OR

Description

U0126 is a highly selective inhibitor of both MEK1 (IC50 of 72nM) and MEK2 (IC50 of 58 nM). U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-related kinase (ERK) and mammalian target of rapamycin (mTOR)-p70(S6K) pathways. The effects of U0126 on the growth of eight human breast cancer cell lines have shown that U0126 selectively represses anchorage-independent growth of MDA-MB231 and HBC4 cells, two lines with constitutively activated ERK. Upon treatment with U0126, cells deprived of anchorage entered apoptosis.


 

U0126

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Details

TECHNICAL INFORMATION

Other Names: 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene

Chemical Formula: C18H16N6S2

CAS Number: 109511-58-2

Molecular Weight: 380.49

Purity:  99% pure

Appearance: White solid

Melting Point: 156°- 159°C

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 200mg/ml. U0126 is very poorly soluble in ethanol and water. The maximum solubility in water is estimated to be 10-50µl.  

 

 

References

 

Tech Docs