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Y27632

2 mg

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Cat No. 53-B85

Availability: In stock

$89.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Y27632 (dihydrochloride) is a highly potent ATP-competitive inhibitor of Rho– associated coiled-coil forming protein serine/threonine kinase (ROCK). It has been shown to prevent dissociation-induced apoptosis in human embryonic stem cells (hES cells). Y27632 enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

Y27632

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  • Y27632 Structure
  • Y27632

Details

TECHNICAL INFORMATION

Other Names: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

Chemical Formula: C14H21N3O· 2HCl

CAS Number: 146986-50-7

Molecular Weight: 320.3

Purity:  >98% by HPLC

Appearance: White crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10mM stock solution of Y27632, reconstitute the compound by adding 624μl of DMSO to the entire contents of the vial. Incubate in a 37°C water bath for 5 minutes if precipitate is observed. For most cells, the maximum tolerance to DMSO is <0.5%.

 

References

 

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