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Quick Overview

SB431542 is a selective and potent inhibitor of TGFβ superfamily type I activin receptor-like kinase (ALK) receptor, specifically ALK4, ALK5 and ALK7. It does not affect BMP receptors ALK2, ALK3 or ALK6. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. When used in combination with MEK inhibitor PD0325901, SB431542 has been found to enhance reprogramming efficiency.