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Quick Overview

PD98059 is a highly selective noncompetitive inhibitor of MEK1 and MEK2. It prevents the activation of MAPKK1 by Raf or MEK kinase with an IC50 of 2-7µM, but does not inhibit Raf-activated MAPKK1.  At concentrations up to 100µM, PD98059 does not inhibit activation of MKK3 or SEK as determined by measuring phosphorylation at its activation site. PD98059 has been shown to inhibit cell growth and proliferation in acute myelogenous leukemia (AML) cell lines and causes G1 arrest by blocking p53-dependent p21 induction.