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Quick Overview

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. It has been shown to arrest the G0/G1 phase of FGFR3– expressing cells.  PD173074 blocks the FGFR signaling pathway and leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 has been shown to dramatically decrease their differentiation potential and clonogenicity.