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Quick Overview

XAV939 is a cell permeable, small molecule inhibitor of the Wnt/β– catenin pathway. It inhibits tankyrase 1 (IC₅₀= 11nM)and tankyrase 2 (IC₅₀=4nM), stabilizes axin and stimulates β-catenin degradation.  Small molecule XAV939 has also been shown to inhibit proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.