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Quick Overview

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (P13K) inhibitor. Inhibitor of the P13K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Wortmannin has been shown to block many of the short-term metabolic effects induced by insulin receptor activation by the inhibition of P13K.