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IWR-1 endo

5 mg

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Cat No. 35-H18

Availability: In stock


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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.



Wnt signaling proteins are small secreted proteins active in embryonic development, tumorigenesis and tissue homeostasis.  IWR-1 endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 of 180nM.  IWR-1 endo inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and Gsk3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or Gsk3β. In in vivo tests , IWR-1 endo has been shown to inhibit zebrafish tail fin regeneration at a minimum inhibitory concentration of 0.5 µM.

IWR-1 endo

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Other Names: 4-​[(3aR,​4S,​7R,​7aS)-​1,​3,​3a,​4,​7,​7a-​hexahydro-​1,​3-​dioxo-​4,​ 7-​methano-​2H-​isoindol-​2-​yl]-​N-​8-​quinolinyl-​benzamide

Chemical Formula:  C25H19N3O3

CAS Number: 1127442-82-3

Molecular Weight: 409.4

Purity:  >98%

Appearance:  a crystalline solid 

Solubility: DMSO



Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.



Soluble in DMSO to 100mM. If precipitate is observed,  vortex for 5 minutes.




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