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Tyrphostin AG 490

10 mg

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Cat No. 22-B79

Availability: In stock


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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.



Tyrphostin AG 490 is a specific and potent JAK-2 protein tyrosine kinase inhibitor.  It has been shown to inhibit EGF receptor autophosphorylation, DNA synthesis and cell growth. It induces apoptosis with no deleterious effect on normal hematopoiesis. Tyrphostin AG 490 has been shown to inhibit the growth of leukemic cells in vitro and in vivo. This compound is a valuable tool for studying the cellular role of JAK kinases in signal transduction.


Tyrphostin AG 490

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Other Names: 2-​cyano-​3-​(3,​4-​dihydroxyphenyl)-​N-​(phenylmethyl)-​2-​propenamide

Chemical Formula:  C17H14N2O3

CAS Number: 133550-38-8

Molecular Weight: 294.3

Purity:  >98%

Appearance:  crystalline solid

Solubility: DMSO, ethanol



Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.



Soluble in DMSO at 200mg/ml. Soluble in ethanol at 16mg/ml. Very poorly soluble in water.




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