Other Names: 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
Chemical Formula: C19H23N7O2
CAS Number: 896466-04-9
Molecular Weight: 381.43
IC50= Aurora A: 3nM, Aurora B: 3nM, JAK2: 1.2nM
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO. Soluble at 76mg/ml
Santo, L., et al (2011). Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent aurora kinase and Stat3 inhibition either alone or in combination with lenalidomide. Cin. Cancer Res. 17:3259-71.