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BAY 11-7082

10 mg

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Cat No. 82-X11

Availability: In stock

$75.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation. The transcription factor NF-κB plays a key role in regulating over 150 target genes that include the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules.  Bay 11-7082 selective and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting IκB-α phosphorylation.  BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1.


 

BAY 11-7082

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TECHNICAL INFORMATION

Other Names: (E)-3-[(4-methylphenylsulfonyl]-2- propenenitrile

Chemical Formula:  C10H9NO2S

CAS Number: 19542-67-7

Molecular Weight: 207.3

Purity:  >98%

Appearance:  a crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at >20 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

 

References

 

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