Other Names: N-[(3,5-Difluorophenyl)acetyl]-L-al
anyl-2-phenyl]glycine-1,1-dimethylethyl ester, LY-374973
Chemical Formula: C23H26F2N2O4
CAS Number: 208255-80-5
Molecular Weight: 432.46
Appearance: a crystalline solid
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO. For a 10mM concentrated stock solution, add 1.16 ml to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.
Morohashi et al. (2006) C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J Biol Chem. 281(21):14670-6.